The 50 were arrested for fraud, corruption and other illegal activities and it is suspected that some of the crimes are committed in cohorts with Zimbabwe Government workers at the border.
Masvingo Mirror reported that the suspects, who include senior SA immigration officers and Police, were apprehended during a crime prevention operation between Home Affairs and the Hawks last week.
It is suspected that the officials arrested were aiding human traffickers, smuggling rings and drug and cigarette traffickers working with organised syndicates on the Zimbabwean side.
Media reports said the 50 were expected to appear before a Musina court last Friday although no further reports have been published.
Earlier reports quoted SA Home Affairs minister Malusi Gigaba applauding the arrests, saying it demonstrated that his department is serious about fighting illegal activities.
His Zimbabwean counterpart Ignatious Chombo who recently visited Beitbridge and said his Government was losing about 50 percent of the possible revenue from Beitbridge through corruption.